Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Carboxyfluorescein) is a high-purity, fluorescently labeled phospholipid essential for advanced membrane biophysics and cell biology research. Its core value lies in enabling the direct, real-time visualization and quantification of lipid dynamics, membrane fusion, and cellular uptake processes. This compound is critically needed by pharmaceutical R&D teams, academic research institutions, and diagnostic developers working on lipid nanoparticle (LNP) formulation, drug delivery system tracking, and fluorescence-based bioassays.

Application

• Lipid Nanoparticle (LNP) Research & Development: As a fluorescent tracer for tracking the formulation, stability, and cellular delivery of mRNA and siRNA therapeutics.
• Membrane Biophysics Studies: For investigating lipid bilayer properties, membrane fluidity, fusion events, and vesicle trafficking using fluorescence microscopy and spectroscopy.
• Cell Biology & Imaging: Labeling of cell membranes to study endocytosis, phagocytosis, and intracellular lipid transport pathways.
• Drug Delivery System Analysis: Visualizing the biodistribution, targeting efficiency, and uptake mechanisms of liposomal and other lipid-based drug carriers.
• Diagnostic Assay Development: Serving as a key component in fluorescence resonance energy transfer (FRET)-based assays for high-throughput screening.
• Model Membrane Preparation: Incorporation into liposomes and supported lipid bilayers (SLBs) for controlled in vitro studies.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Carboxyfluorescein)
CAS No.	799268-49-8
Molecular Formula	C95H153N2O19P
Molecular Weight	1682.2 g/mol
Synonyms	DOPE-CF; DOPE-Carboxyfluorescein; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein); N-(Carboxyfluorescein)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Fluorescein-DOPE; CF-DOPE; N-(Fluorescein-5-thiocarbamoyl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Fluorescent DOPE
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Carboxyfluorescein) is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry for identity confirmation, and fluorescence spectroscopy for performance validation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Under these recommended conditions, the product is stable for at least 24 months. Allow the vial to warm to room temperature before opening to minimize moisture condensation. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (MS)	Complies
Purity (HPLC)	≥ 95%
Fluorescence Properties	Ex/Em ~492/518 nm (pH >7)
Solubility	Chloroform, Methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.