Description

n-W,W-Dimethy-D-Arginine(Asymmetrical) is a high-purity, asymmetrically dimethylated derivative of D-arginine, a non-natural stereoisomer of the essential amino acid. This specific modification is critical for advanced biochemical research and pharmaceutical development, particularly in the study of protein arginine methylation and its role in cellular regulation. It serves as a key building block and reference standard for researchers and manufacturers in the life sciences sector, enabling precise investigations into epigenetics, signal transduction, and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel peptide-based drugs and protease inhibitors.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to protein arginine methyltransferases (PRMTs) to explore epigenetic mechanisms.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in HPLC and LC-MS assays within QC laboratories.
• Peptide Synthesis: Incorporated into custom peptide sequences to study the effects of asymmetric dimethylarginine (ADMA) on protein structure, function, and protein-protein interactions.
• Diagnostic Development: Potential use in developing assays and kits for detecting and quantifying methylated arginine residues in biological samples.
• Academic Research: Essential tool for universities and research institutes studying cardiovascular disease, neurology, and cancer, where arginine methylation pathways are implicated.

Basic Information

Item	Detail
Product Name	n-W,W-Dimethy-D-Arginine(Asymmetrical)
CAS No.	783265-75-8
Molecular Formula	C8H18N4O2
Molecular Weight	202.25 g/mol
Synonyms	Asymmetric ω-N,ω-N-Dimethyl-D-arginine; D-ADMA; D-Asymmetric dimethylarginine; (2R)-2-Amino-5-[(amino-dimethylaminomethylene)amino]pentanoic acid; H-D-Arg(Me)2-OH; D-NG,NG-Dimethylarginine; (R)-2-Amino-5-((E)-(dimethylamino)(imino)methyl)amino)pentanoic acid
EINECS	Contact for details

Quality Control

Every batch of n-W,W-Dimethy-D-Arginine(Asymmetrical) is manufactured and tested under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and compliance with your research or cGMP guidelines. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity, assay, and impurity profiles determined by HPLC, MS, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions after opening to maintain stability and purity. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.