Description

Tos-Peg10-Ch2Ch2Cootbu CAS NO 778596-20-6 is a specialized polyethylene glycol (PEG)-based linker molecule featuring a terminal tert-butyl ester group and a tosylate (p-toluenesulfonate) leaving group. This bifunctional structure is engineered to facilitate controlled conjugation and bioconjugation strategies in advanced chemical synthesis. It serves as a critical reagent for researchers and manufacturers developing pharmaceuticals, diagnostic agents, and novel biomaterials. The compound's design enables precise attachment and spacing between functional molecules, making it essential for creating targeted drug delivery systems and functionalized surfaces.

Application

• Pharmaceutical Linker: A key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics, where it provides a cleavable or stable PEG spacer.
• Proteomics Research: Used for site-specific protein and peptide modification, enabling studies on protein function, interaction, and labeling.
• Polymer Chemistry: Serves as a functional initiator or monomer in the synthesis of tailored, biodegradable, or stimuli-responsive polymeric materials.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents and fluorescent probes for medical imaging and in vitro diagnostics.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and chromatographic media with specific chemical handles for further coupling.
• Cross-linking Agent: Facilitates the controlled cross-linking of biomolecules or polymers to form hydrogels or stabilized complexes.

Basic Information

Product Name	Tos-Peg10-Ch2Ch2Cootbu
CAS No.	778596-20-6
Molecular Formula	C31H64O15S
Molecular Weight	708.9 g/mol
Synonyms	2,5,8,11,14,17,20,23,26,29-Decaoxa-32-thiaheptatriacontane-1,37-dioic acid, 37-(1,1-dimethylethyl) ester, 1-(4-methylbenzenesulfonate); tert-Butyl 3,6,9,12,15,18,21,24,27,30-decaoxa-33-azapentatriacontan-35-oate 33-(4-methylbenzenesulfonate); α-tert-Butoxy-ω-tosyl-PEG10-acetic acid; TBTA-PEG10-OTs; tert-Butyl-PEG10-tosylate; Tos-PEG10-t-butyl ester; PEG10 spacer with tosylate and t-butyl ester termini; 4-Methylbenzenesulfonic acid PEG10 tert-butyl ester derivative
EINECS	Contact for details

Quality Control

Our Tos-Peg10-Ch2Ch2Cootbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support compliance with relevant regulatory frameworks for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by NMR titration)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.