Description

4-(Methylamino)-1-(3-Pyridyl-D4)-1-Butanone Dihydrochloride is a deuterated derivative of a key intermediate used in the synthesis of active pharmaceutical ingredients (APIs). This compound is critical for conducting metabolism and pharmacokinetic studies, providing essential data for drug development and regulatory approval. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of analytical reference standards who require high-purity, isotopically labeled materials for advanced research.

Application

• Metabolite Identification and Tracing in preclinical and clinical pharmacokinetic (PK) studies.
• Internal Standard for Quantitative Bioanalysis using LC-MS/MS and GC-MS methods, ensuring accurate measurement of drug concentrations in biological matrices.
• Synthesis of Deuterated Drug Candidates for investigating isotope effects on metabolism and bioavailability.
• Stable Isotope Labeling in mass spectrometry-based proteomics and metabolomics research.
• Reference Material for Forensic and Doping Control Analysis, providing definitive identification benchmarks.
• Chemical Intermediate in the custom synthesis of novel, labeled pharmaceutical compounds.

Basic Information

Product Name	4-(Methylamino)-1-(3-Pyridyl-D4)-1-Butanone Dihydrochloride
CAS No.	764661-23-6
Molecular Formula	C11H15D4Cl2N2O
Molecular Weight	262.21 g/mol
Synonyms	4-(Methylamino)-1-(3-pyridinyl-d4)-1-butanone dihydrochloride; 1-(Pyridin-3-yl-d4)-4-(methylamino)butan-1-one dihydrochloride; Deuterated Nicotine Metabolite Intermediate; Cotinine-d4 Dihydrochloride Derivative; 3-Pyridyl-D4-4-(Methylamino)butanone Dihydrochloride; N-Methyl-4-oxo-4-(pyridin-3-yl-d4)butan-1-aminium chloride
EINECS	Contact for details

Quality Control

Every batch of 4-(Methylamino)-1-(3-Pyridyl-D4)-1-Butanone Dihydrochloride is produced and analyzed under strict quality management systems. We provide comprehensive analytical data to confirm identity, chemical purity, and isotopic enrichment, ensuring consistency for sensitive analytical applications. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and isotopic purity are available for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.