Description

Mal-Peg1-Acid CAS NO 760952-64-5 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group at one terminus and a carboxylic acid at the other. This molecular architecture is critical for creating stable, site-specific bioconjugates, enabling the precise attachment of biomolecules like peptides, proteins, and antibodies. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced drug delivery systems who require reliable, high-purity linkers for their conjugation workflows.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via the thiol-reactive maleimide group.
• PEGylation of Peptides/Proteins: Conjugation through the carboxylic acid group to amine functionalities, introducing a short PEG spacer to improve solubility, stability, and pharmacokinetics.
• Diagnostic Probe Synthesis: Creating fluorescent or enzyme-labeled detection reagents for immunoassays and biosensors.
• Surface Functionalization: Immobilizing biomolecules onto nanoparticles, microspheres, or biosensor chips to create bioactive surfaces.
• Cross-linking Agent: For connecting two different molecules, one containing a thiol and the other an amine group, in a controlled manner.
• Biomaterial Modification: Incorporating functional handles into hydrogels or polymer scaffolds for tissue engineering applications.

Basic Information

Product Name	Mal-Peg1-Acid
CAS No.	760952-64-5
Molecular Formula	C9H11NO5
Molecular Weight	213.19 g/mol
Synonyms	3-Maleimidopropionic Acid; Maleimide-PEG1-acid; 1-(2-Carboxyethyl)pyrrole-2,5-dione; 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic Acid; Mal-PEG1-COOH; Maleimido-PEG1-acid; PEG1-maleimide-acid; 3-Maleimidopropanoic Acid
EINECS	Contact for details

Quality Control

Our Mal-Peg1-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Maleimide Content (Titration)	≥ 90%
Acid Value (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.