Description

n-(2-Azidoacetyl)-Neuraminicacid is a chemically modified derivative of sialic acid, featuring a reactive azidoacetyl group. This functionalization makes it a critical intermediate for bioorthogonal chemistry, enabling site-specific labeling and conjugation of biomolecules. It is primarily utilized by researchers and manufacturers in the fields of glycobiology, pharmaceutical development, and diagnostic reagent production.

Application

• Bioconjugation and Labeling: Key reagent for click chemistry reactions (e.g., CuAAC, SPAAC) to attach fluorophores, biotin, or other probes to glycoproteins, glycolipids, or cell surfaces.
• Glycoprotein Engineering: Used in the chemoenzymatic synthesis of modified sialoglycoconjugates for studying structure-function relationships.
• Antiviral Research: Serves as a precursor or inhibitor analog in the development of neuraminidase-targeting therapeutics for influenza and other viral infections.
• Diagnostic Development: Intermediate in the production of detection reagents for assays targeting sialic acid-binding pathogens or biomarkers.
• Chemical Biology Probes: Enables the creation of activity-based probes to study sialyltransferase enzymes and sialidase activity in complex biological systems.
• Vaccine Adjuvant Research: Investigated for its potential role in modulating immune responses through sialic acid-dependent pathways.

Basic Information

Product Name	n-(2-Azidoacetyl)-Neuraminicacid
CAS No.	756823-87-7
Molecular Formula	C13H20N4O9
Molecular Weight	376.32 g/mol
Synonyms	5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid 2-azidoacetate; 2-Azidoacetamido-2-deoxyneuraminic acid; N-Azidoacetylneuraminic acid; Azidoacetyl Neu5Ac; N-(Azidoacetyl)-D-neuraminic acid; Sialic acid azidoacetyl derivative; 9-Azidoacetamido-9-deoxy-N-acetylneuraminic acid
EINECS	Contact for details

Quality Control

Our n-(2-Azidoacetyl)-Neuraminicacid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the container to reach room temperature before opening to minimize moisture condensation. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.