Description

α-Maleimidopropionyl-ω-Succinimidyl-8(Ethylene Glycol) is a heterobifunctional, amine- and sulfhydryl-reactive crosslinker featuring a hydrophilic polyethylene glycol (PEG) spacer. This compound is engineered for the stable, site-specific conjugation of biomolecules, such as antibodies and proteins, while minimizing aggregation and preserving biological activity. It is a critical reagent for researchers and manufacturers in bioconjugation, diagnostic assay development, and ADC (Antibody-Drug Conjugate) linker-payload synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For the controlled attachment of cytotoxic payloads to monoclonal antibodies via stable thioether bonds.
• Protein/Peptide Labeling & Immobilization: Conjugation of enzymes, fluorescent dyes, or other probes to proteins for diagnostic and research applications.
• Surface Functionalization: Modification of nanoparticles, biosensors, or chromatography resins with bioactive ligands.
• PEGylation Strategies: Introducing hydrophilic PEG spacers to improve the solubility, stability, and pharmacokinetics of therapeutic biomolecules.
• Crosslinking for Structural Studies: Investigating protein-protein interactions or stabilizing protein complexes for analysis.
• Diagnostic Reagent Manufacturing: Production of enzyme-antibody conjugates used in ELISA, lateral flow assays, and other immunoassays.

Basic Information

Product Name	α-Maleimidopropionyl-ω-Succinimidyl-8(Ethylene Glycol)
CAS No.	756525-93-6
Molecular Formula	C31H48N4O15
Molecular Weight	716.73 g/mol
Synonyms	Maleimide-PEG8-NHS ester; NHS-PEG8-Maleimide; SM(PEG)8; Succinimidyl-[(N-maleimidopropionamido)-octaethyleneglycol] ester; MAL-PEG8-NHS; 8-Arm PEG NHS Ester Maleimide; α-Maleimidopropionyl-ω-succinimidyl octa(ethylene glycol); Heterobifunctional PEG Crosslinker, NHS-PEG-MAL
EINECS	Contact for details

Quality Control

Our α-Maleimidopropionyl-ω-Succinimidyl-8(Ethylene Glycol) is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and GMP-grade applications. Each lot is characterized by NMR, HPLC, and mass spectrometry to confirm structure, purity, and functional group integrity. Comprehensive Certificates of Analysis (COA) detailing purity, moisture content, and functional assay are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Assay (NHS Ester)	≥ 90%
Functional Assay (Maleimide)	≥ 90%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.