Description

α-Maleimidopropionyl-ω-Succinimidyl-12(Ethylene Glycol) is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and an N-hydroxysuccinimide (NHS) ester. This compound matters for its ability to create stable, site-specific conjugates between thiol-containing biomolecules (like antibodies or peptides) and amine-containing targets, a critical process in bioconjugation and therapeutic development. It is essential for researchers and manufacturers in biopharmaceuticals, diagnostics, and advanced materials science who require precise and reliable protein modification, drug delivery system assembly, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues.
• Protein/Peptide PEGylation: Attachment of PEG chains to amines on proteins to improve solubility, stability, and pharmacokinetics.
• Diagnostic Assay Development: Immobilization of antibodies or antigens onto amine-functionalized surfaces (e.g., microplates, beads, biosensors).
• Nanoparticle Functionalization: Conjugation of targeting ligands (with thiols) to amine-coated nanoparticles for targeted drug delivery.
• Biomaterial Crosslinking: Creating hydrogel networks or modifying biomaterial surfaces for tissue engineering applications.
• Enzyme Modification: Stabilizing enzymes or altering their properties by controlled PEGylation.
• Fluorescent Probe Conjugation: Labeling proteins or peptides with fluorescent dyes for imaging and tracking studies.

Basic Information

Product Name	α-Maleimidopropionyl-ω-Succinimidyl-12(Ethylene Glycol)
CAS No.	756525-92-5
Molecular Formula	C37H58N4O19
Molecular Weight	862.88 g/mol
Synonyms	Maleimide-PEG12-NHS ester; MAL-PEG12-NHS; NHS-PEG12-MAL; 12-Amino-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxanonatriacontane-1,39-dioic acid, 39-[2,5-dioxo-1-pyrrolidinyl] ester, 1-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-; PEG12 crosslinker; SM(PEG)12; Heterobifunctional PEG12 linker; Succinimidyl 3-maleimidopropionamido-dodecaethyleneglycol ester
EINECS	Contact for details

Quality Control

Our α-Maleimidopropionyl-ω-Succinimidyl-12(Ethylene Glycol) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and functional group titration, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the functional groups are susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Assay (Maleimide)	≥ 90%
Functional Group Assay (NHS ester)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.