Description

4-Aminobutyl-Dota is a bifunctional chelating agent of significant importance in the field of radiopharmaceutical chemistry. Its core value lies in its ability to form exceptionally stable complexes with diagnostic and therapeutic radionuclides, such as Lutetium-177 and Gallium-68. This compound is essential for researchers and manufacturers developing next-generation targeted radiopharmaceuticals for oncology and medical imaging. The product is supplied under strict quality control to ensure batch-to-batch consistency for critical research and development applications.

Application

• Radiopharmaceutical Precursor: Serves as a key intermediate for synthesizing peptide- and antibody-based radiopharmaceuticals for targeted cancer therapy (e.g., Prostate-Specific Membrane Antigen (PSMA)-targeted agents).
• Diagnostic Imaging Probes: Used in the development of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging agents by chelating isotopes like Ga-68 and In-111.
• Theragnostic Agent Development: Enables the creation of theragnostic pairs, where the same targeting vector is labeled with different isotopes for both diagnosis and treatment.
• Bifunctional Chelator (BFC) Research: A critical tool in academic and industrial research for studying metal-chelate chemistry, conjugation techniques, and in vivo stability of radiolabeled compounds.
• Conjugation to Biomolecules: The primary amine group allows for efficient conjugation to peptides, antibodies, proteins, and other targeting molecules via standard coupling chemistry.
• Metal Ion Scavenging & Separation: Applied in specialized chemical processes and analytical methods for the selective binding and separation of lanthanide and actinide metal ions.

Basic Information

Item	Detail
Product Name	4-Aminobutyl-Dota
CAS No.	753421-63-5
Molecular Formula	C22H41N5O8
Molecular Weight	503.59 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 10-[4-(Amino)butyl]amide; DOTA-(4-aminobutyl)amide; 4-Aminobutyl-DOTA; DOTA-Bn-NH2; DOTA-NH-(CH2)4-NH2; p-SCN-Bn-DOTA precursor; Bifunctional DOTA chelator; AAZTA-like chelator derivative
EINECS	Contact for details

Quality Control

Our 4-Aminobutyl-Dota is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research. Each batch is characterized by HPLC, NMR, and Mass Spectrometry to confirm identity, purity, and absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.