Description

H-Arg-Lys(Dabcyl)-Thr-Ser-Gly-Pro-Asn-Gln-Glu-Gln-Glu(Edans)-Arg-Oh is a specialized, high-purity peptide sequence containing the FRET (Förster Resonance Energy Transfer) pair Dabcyl and Edans. This compound is critical for advanced biochemical research and diagnostic development, enabling precise, real-time monitoring of enzymatic activity. It is primarily utilized by research institutions and biotechnology companies focused on protease and peptidase assay development, drug discovery, and molecular diagnostics.

Application

• Protease/Peptidase Activity Assays: Serves as a highly sensitive FRET-based substrate for quantifying enzyme kinetics and inhibition studies.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel therapeutic compounds targeting specific proteolytic enzymes.
• Diagnostic Kit Development: A key component in the development of in vitro diagnostic (IVD) tests for diseases involving abnormal protease activity.
• Biochemical Research: Enables fundamental research into protein-protein interactions, signal transduction pathways, and apoptosis mechanisms.
• Quality Control in Biologics: Employed to assess the activity and purity of enzyme-based biopharmaceutical products during manufacturing.

Basic Information

Product Name	H-Arg-Lys(Dabcyl)-Thr-Ser-Gly-Pro-Asn-Gln-Glu-Gln-Glu(Edans)-Arg-Oh
CAS No.	742080-61-1
Molecular Formula	C86H130N28O27S2
Molecular Weight	1996.26 g/mol
Synonyms	FRET Peptide Substrate Dabcyl-Edans; Arg-Lys(Dabcyl)-Thr-Ser-Gly-Pro-Asn-Gln-Glu-Gln-Glu(Edans)-Arg; Dabcyl-QSGPIQSK(Edans)FR-OH (common sequence alias); H-Arg-Lys(5-((2-Aminoethyl)amino)naphthalene-1-sulfonyl)-Thr-Ser-Gly-Pro-Asn-Gln-Glu-Gln-Glu(5-((2-Aminoethyl)amino)naphthalene-1-sulfonyl)-Arg-OH; Caspase-3/7 FRET Substrate (related class); Protease Fluorescent Substrate; EDANS/DABCYL Peptide; Dabcyl-Glu-Arg-Asp-Glu-Val-Asp-Glu(Edans)-OH (structural variant).
EINECS	Contact for details

Quality Control

Every batch of our FRET peptide substrates is manufactured and analyzed under strict quality management systems. We guarantee high purity (typically >95% by HPLC) and precise characterization to ensure consistent performance in sensitive assays. Comprehensive testing includes identity confirmation by Mass Spectrometry (MS) and purity assessment by analytical HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Water, or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.