Description

n-(6-Aminohexyl)Maleimide Trifluoroacetate Salt is a heterobifunctional crosslinking reagent featuring a maleimide group and a primary amine, separated by a six-carbon alkyl spacer. This compound is critically important for the site-specific conjugation of biomolecules, enabling the creation of stable thioether bonds with sulfhydryl groups while offering a primary amine for further modification or coupling via carbodiimide chemistry. It is an essential tool for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, peptide synthesis, and surface functionalization for biosensors and diagnostics.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Used to covalently attach cytotoxic drugs to monoclonal antibodies via thiol-maleimide coupling.
• Protein and Peptide Labeling: Enables the site-specific introduction of fluorophores, biotin, or other probes onto cysteine residues.
• Surface Immobilization: Functionalizes gold surfaces, nanoparticles, or chips with amine-reactive groups for biosensor and microarray fabrication.
• Polymer Modification: Serves as a crosslinker or functional monomer for synthesizing smart polymers and hydrogels with reactive handles.
• Enzyme Stabilization: Used in the preparation of immobilized enzymes for biocatalysis and industrial processes.
• Diagnostic Reagent Synthesis: A key intermediate in the production of labeled antigens, antibodies, and other immunoassay components.

Basic Information

Item	Detail
Product Name	n-(6-Aminohexyl)Maleimide Trifluoroacetate Salt
CAS No.	731862-92-3
Molecular Formula	C₁₃H₁₉F₃N₂O₄
Molecular Weight	324.30 g/mol
Synonyms	6-Maleimidohexylamine Trifluoroacetate; N-(6-Aminohexyl)maleimide TFA Salt; AHM TFA; 1-(6-Aminohexyl)-1H-pyrrole-2,5-dione Trifluoroacetate; Maleimidocaproylamine TFA Salt; N-(6-Amino-n-hexyl)maleimide Trifluoroacetate; 6-Maleimidocaproic Acid Amide TFA Salt; Amino-C6-Maleimide TFA Salt
EINECS	Contact for details

Quality Control

Our n-(6-Aminohexyl)Maleimide Trifluoroacetate Salt is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed by HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.