Description

Calpain-2 is a calcium-dependent cysteine protease enzyme that plays a critical role in intracellular signaling and cytoskeletal remodeling. This specific inhibitor, referenced as CAS NO 702693-80-9, is an essential research tool for studying cellular processes such as apoptosis, cell motility, and neurodegeneration. It is primarily utilized by researchers and developers in the fields of biochemical research, pharmaceutical development, and diagnostic assay manufacturing to precisely modulate calpain activity in experimental models.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific functions of calpain-2 in signal transduction pathways and disease mechanisms.
• Neurodegenerative Disease Studies: Applied in research models for Alzheimer's, Parkinson's, and traumatic brain injury to investigate calpain's role in neuronal death.
• Cardiovascular Research: Utilized to examine the involvement of calpain-2 in cardiac hypertrophy, ischemia-reperfusion injury, and atherosclerosis.
• Muscle Biology: Employed in studies of muscular dystrophy and exercise-induced muscle adaptation where calpain-mediated protein turnover is key.
• Pharmaceutical Screening: Serves as a reference compound or positive control in high-throughput screens for novel calpain inhibitor drug candidates.
• Cell Culture & Model Systems: Added to cell-based assays to inhibit calpain-2 activity, helping to elucidate its role in cell migration, proliferation, and differentiation.

Basic Information

Product Name	Calpain-2
CAS No.	702693-80-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Calpain II; CANP 2; m-Calpain; Calcium-activated neutral proteinase 2; Millimolar-calpain; Calpain-2 Inhibitor; CAS 702693-80-9; Calpain 2 Selective Inhibitor
EINECS	Contact for details

Quality Control

Our Calpain-2 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including purity verification and functional activity assays. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Biological Activity (IC50)	Specified per COA
Solubility	Specified per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.