Description

Glutaryl-Ala-Ala-Phe 4-Methoxy-β-Naphthylamide is a specialized synthetic peptide substrate designed for enzymatic research and diagnostic applications. This compound is a critical reagent for the specific and sensitive detection of protease activity, particularly for enzymes like cathepsin C (dipeptidyl peptidase I). It is essential for researchers and manufacturers in the fields of biochemistry, pharmaceutical development, and clinical diagnostics who require high-purity, reliable substrates for assay development and quality control.

Application

• Protease Activity Assays: Primary substrate for fluorometric and colorimetric detection of cathepsin C and related dipeptidyl peptidases in research settings.
• Biochemical Research: Used in kinetic studies, enzyme characterization, and inhibitor screening to understand protease function and regulation.
• Diagnostic Kit Manufacturing: A key component in the formulation of diagnostic kits for measuring specific protease levels, relevant to conditions like inflammation and certain genetic disorders.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) campaigns to identify and optimize novel therapeutic protease inhibitors.
• Cell Biology Studies: Utilized to monitor protease activity within cellular and tissue lysates, aiding in the study of intracellular protein degradation pathways.

Basic Information

Product Name	Glutaryl-Ala-Ala-Phe 4-Methoxy-β-Naphthylamide
CAS No.	79642-99-2
Molecular Formula	C₃₃H₄₁N₅O₈
Molecular Weight	635.71 g/mol
Synonyms	Glutaryl-Ala-Ala-Phe-4-Methoxy-2-Naphthylamide; Glutaryl-Ala-Ala-Phe-4MβNA; GAAFMNA; Cathepsin C Substrate; Dipeptidyl Peptidase I Substrate; Glt-Ala-Ala-Phe-4-Methoxy-β-Naphthylamide; Glutaryl-L-Alanyl-L-Alanyl-L-Phenylalanyl-4-Methoxy-2-Naphthylamide; Glutaryl-AAF-4MβNA
EINECS	Contact for details

Quality Control

Every batch of Glutaryl-Ala-Ala-Phe 4-Methoxy-β-Naphthylamide is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure they meet the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	95.0% - 105.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.