Description

Ethyl n-Succinimidoxyacetate is a specialized organic ester compound with the CAS registry number 79403-56-8. This chemical serves as a versatile and reactive intermediate, crucial for introducing the succinimidyloxyacetyl moiety into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and bioconjugation sectors for the synthesis of novel active pharmaceutical ingredients (APIs), prodrugs, and labeled compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules and prodrugs requiring a cleavable linker.
• Bioconjugation Reagent: Used for the covalent attachment of drugs, dyes, or other functional groups to proteins, antibodies, or peptides under mild conditions.
• Proteomics Research: Employed in chemical biology for labeling and cross-linking studies to investigate protein structure and function.
• Polymer Modification: Functionalizes polymer backbones to introduce reactive sites for further chemical grafting or to impart specific properties.
• Material Science: Acts as a coupling agent in the surface modification of nanomaterials and solid supports for diagnostic applications.
• Organic Synthesis: Serves as a protected or activated ester form in multi-step synthetic routes for fine chemicals.

Basic Information

Product Name	Ethyl n-Succinimidoxyacetate
CAS No.	79403-56-8
Molecular Formula	C8H11NO5
Molecular Weight	201.18 g/mol
Synonyms	Ethyl N-Succinimidoxyacetate; Ethyl (N-Succinimidyloxy)acetate; N-Hydroxysuccinimide Ethyl Acetate; NHS-Ester Ethyl Acetate; Acetic Acid, 2,5-Dioxo-1-pyrrolidinyl Ester, Ethyl Ester; 2,5-Dioxopyrrolidin-1-yl Ethyl Acetate; Ethyl (2,5-Dioxopyrrolidin-1-yl)oxyacetate; Succinimidyl Ethyl Acetate
EINECS	Contact for details

Quality Control

Our Ethyl n-Succinimidoxyacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.