Description

Iodoacetic Acid, [3H] is a tritium-labeled derivative of iodoacetic acid, a potent alkylating agent used in biochemical research. This radiolabeled compound is essential for tracing and quantifying biochemical pathways, particularly those involving enzyme inhibition and protein modification. It is a critical tool for researchers in pharmaceutical development, proteomics, and metabolic studies who require precise tracking of molecular interactions.

Application

• Biochemical Research: As an active-site directed irreversible inhibitor, used to study enzyme mechanisms, particularly those of cysteine proteases and dehydrogenases.
• Proteomics & Protein Labeling: Employed for alkylating cysteine residues in proteins to investigate structure, function, and protein-protein interactions via radiolabel tracing.
• Metabolic Pathway Analysis: Utilized in tracer studies to elucidate metabolic fluxes and the role of specific enzymatic activities in cellular processes.
• Pharmaceutical Development: Serves as a key reagent in drug discovery for validating drug targets and understanding the mechanism of action of potential therapeutic agents.
• Radioisotope Labeling Studies: Acts as a precursor or direct agent in synthesis for creating other tritium-labeled compounds for advanced research applications.

Basic Information

Product Name	Iodoacetic Acid, [3H]
CAS No.	79347-94-7
Molecular Formula	C₂H₂IO₂ (³H)
Molecular Weight	Contact for details
Synonyms	Tritiated Iodoacetic Acid; [³H]Iodoacetic Acid; 2-Iodo[3-³H]acetic Acid; IAA-[3H]; Radioiodoacetic Acid (³H); Carboxymethyl iodide (³H); (³H)-Iodoacetate
EINECS	Contact for details

Quality Control

Every batch of Iodoacetic Acid, [3H] is manufactured and controlled to meet the stringent requirements of research and development. Our products undergo rigorous quality testing, including radiochemical purity analysis by HPLC and specific activity verification, to ensure consistency and reliability. Certificates of Analysis (COA) detailing batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold temperatures (e.g., -20°C or as specified on the label) in a dedicated, well-ventilated area for radioactive materials. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Clear Solution
Identification (IR/NMR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Chemical Purity (HPLC)	≥ 98%
Solvent	Specified on COA (e.g., Ethanol/Water)
Concentration	Specified on COA (mCi/mL or MBq/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.