Description

1-Phenyl-3-Trimethylaminopropyl Carbodiimide is a specialized carbodiimide reagent widely used as a zero-length coupling agent for the formation of amide bonds. Its primary value lies in facilitating efficient peptide synthesis and bioconjugation reactions under mild conditions, offering high yields with minimal racemization. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors, particularly for the synthesis of peptides, protein cross-linking, and polymer modification.

Application

• Peptide Synthesis: As a key coupling reagent for the condensation of amino acids, minimizing epimerization.
• Bioconjugation: For the covalent attachment of proteins, antibodies, or peptides to other molecules, surfaces, or polymers.
• Polymer Chemistry: Used in the modification and cross-linking of polymers to introduce specific functional groups or create hydrogel networks.
• Organic Synthesis: As a dehydrating agent for the preparation of esters, amides, and other carboxylic acid derivatives.
• Pharmaceutical Intermediates: In the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Material Science: For surface functionalization of nanoparticles and other nanomaterials to tailor their properties.

Basic Information

Product Name	1-Phenyl-3-Trimethylaminopropyl Carbodiimide
CAS No.	79322-24-0
Molecular Formula	C13H19N3
Molecular Weight	217.31 g/mol
Synonyms	1-Phenyl-3-(3'-dimethylaminopropyl)carbodiimide; Phenyl-3-(3-dimethylaminopropyl)carbodiimide; 3-(Dimethylamino)propylphenylcarbodiimide; 1-Phenyl-3-(3-dimethylaminopropyl)carbodiimide; Carbodiimide, 1-phenyl-3-(3-dimethylaminopropyl)-; EDC Analog (Hydrochloride salt form); Phenyl-DMAP-Carbodiimide; (3-Dimethylaminopropyl)-phenyl-carbodiimide
EINECS	Contact for details

Quality Control

Our 1-Phenyl-3-Trimethylaminopropyl Carbodiimide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.