Description

Taurochenodeoxycholic Acid-3-o-Glucuronide-[D4] is a deuterium-labeled analog of a key bile acid metabolite. This compound is essential as a high-purity internal standard for the precise quantification of bile acids in complex biological matrices using advanced analytical techniques. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers engaged in metabolomics, pharmacokinetic studies, and biomarker discovery.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of endogenous bile acid profiles in plasma, serum, and urine.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in ADME studies to track the metabolism of drug candidates that affect bile acid pathways or are conjugated similarly.
• Clinical Diagnostics: Enables the development and validation of sensitive assays for diagnosing hepatobiliary disorders, cholestasis, and metabolic diseases.
• Metabolomics Research: A vital tool for uncovering disease biomarkers and understanding metabolic perturbations in liver and gastrointestinal research.
• Method Development & Validation: Provides a stable isotopic reference for optimizing separation and detection parameters in analytical laboratories.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and ensuring batch consistency for bile acid-related therapeutics.

Basic Information

Product Name	Taurochenodeoxycholic Acid-3-o-Glucuronide-[D4]
CAS No.	79252-49-6
Molecular Formula	C32H47D4NO13S
Molecular Weight	677.8 g/mol (approx.)
Synonyms	3-O-Glucuronosyl-taurochenodeoxycholic Acid-d4; Taurochenodeoxycholic Acid 3-O-β-D-Glucuronide-d4; TCDCA-3G-d4; Chenodeoxycholyltaurine 3-O-Glucuronide-d4; 3α,7α-Dihydroxy-5β-cholan-24-oyltaurine N-(3-O-β-D-glucopyranuronosyl)-d4; Deuterated TCDCA-3G; [D4]-Taurochenodeoxycholic Acid Glucuronide
EINECS	Contact for details

Quality Control

Every batch of Taurochenodeoxycholic Acid-3-o-Glucuronide-[D4] is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity verified by NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.