Description

5Alpha-Androstan-17Beta-Ol-3-One-16,16,17-D3 is a high-purity, deuterium-labeled steroid derivative, specifically a trideuterated form of dihydrotestosterone (DHT). This compound is of significant value as a stable isotope-labeled internal standard in analytical chemistry, ensuring precise quantification and method validation. It is primarily required by pharmaceutical research laboratories, clinical diagnostic developers, and forensic toxicology facilities engaged in advanced mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS/MS) workflows for hormone analysis and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous androgenic steroids, including dihydrotestosterone (DHT), in biological matrices such as serum, plasma, and tissue homogenates.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetic (DMPK) studies for investigational drugs targeting androgen pathways, enabling precise tracking of drug effects on hormone levels.
• Clinical Diagnostics: Essential for developing and validating high-sensitivity assays to diagnose and monitor disorders related to androgen excess or deficiency.
• Forensic & Anti-Doping Analysis: Employed in confirmatory testing for the detection of anabolic steroid abuse in sports and forensic investigations, providing legally defensible results.
• Endocrinology Research: Facilitates fundamental research into androgen receptor signaling, steroidogenesis, and the role of DHT in conditions like benign prostatic hyperplasia (BPH) and androgenic alopecia.
• Biomarker Discovery: Supports metabolomics and steroid profiling studies aimed at identifying novel biomarkers for various diseases.

Basic Information

Product Name	5Alpha-Androstan-17Beta-Ol-3-One-16,16,17-D3
CAS No.	79037-34-6
Molecular Formula	C19H27D3O2
Molecular Weight	293.47 g/mol
Synonyms	Dihydrotestosterone-16,16,17-d3; 5α-Dihydrotestosterone-d3; 17β-Hydroxy-5α-androstan-3-one-16,16,17-d3; 5α-Androstan-17β-ol-3-one-16,16,17-d3; DHT-d3; Androstanolone-d3; 5α-DHT-d3; NSC 137671-d3
EINECS	Contact for details

Quality Control

Our 5Alpha-Androstan-17Beta-Ol-3-One-16,16,17-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and solvent residues. We adhere to relevant industry standards for reference materials, and our quality commitment ensures reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or Certificate of Analysis. For long-term storage, consider storing at -20°C under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.