Description

3-Hydroxy-3-Methyl-4-Carboxybutyl-Coenzyme A is a specialized biochemical intermediate, a key metabolite in the mevalonate pathway essential for isoprenoid and sterol biosynthesis. Its primary commercial value lies in its critical role as a research standard and reagent for enzymatic studies, metabolic pathway analysis, and drug discovery targeting cholesterol synthesis. This high-purity compound is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on metabolic disorders, lipid biochemistry, and enzyme kinetics.

Application

• Enzymology Research: Serves as a critical substrate for studying the enzyme HMG-CoA reductase, a major pharmaceutical target.
• Metabolic Pathway Analysis: Used as a reference standard in the mevalonate pathway to investigate sterol and isoprenoid biosynthesis.
• Pharmaceutical Development: Employed in screening and development of novel statins and other lipid-lowering agents.
• Biochemical Assays: Acts as a key component in in vitro diagnostic and research assays for metabolic function.
• Academic Research: Utilized in university and institutional labs for fundamental studies in biochemistry and cell biology.
• Reference Standard: Provides a high-purity calibrant for analytical methods like HPLC and LC-MS in quality control and research settings.

Basic Information

Product Name	3-Hydroxy-3-Methyl-4-Carboxybutyl-Coenzyme A
CAS No.	78901-91-4
Molecular Formula	C27H44N7O19P3S
Molecular Weight	911.65 g/mol
Synonyms	HMG-CoA; 3-Hydroxy-3-methylglutaryl-CoA; Hydroxymethylglutaryl Coenzyme A; (S)-HMG-CoA; (3S)-3-Hydroxy-3-methylglutaryl-CoA; 3-Hydroxy-3-methylglutaryl-coenzyme A; β-Hydroxy-β-methylglutaryl-CoA; Coenzyme A, S-(3-hydroxy-3-methylglutaryl)-
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3-Methyl-4-Carboxybutyl-Coenzyme A is produced under stringent conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, spectroscopic identification (UV, NMR), and verification of biological activity. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 90%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.