Description

γ-Sanshool CAS NO 78886-65-4 is a bioactive alkylamide compound primarily responsible for the characteristic tingling and numbing sensation associated with Szechuan pepper. This compound matters for its unique pharmacological profile, acting as a selective agonist for the KCNK family of potassium channels, which drives its sensory effects and research interest. It is needed by researchers in the flavor and fragrance industry for sensory modulation, by pharmaceutical developers investigating novel topical analgesics or oral sensates, and by nutraceutical companies exploring functional food ingredients.

Application

• Flavor & Fragrance Industry: Used as a key sensory component to create authentic tingling, numbing, or "mouth-tingling" effects in food and beverage products, particularly those aiming to replicate the sensation of Szechuan pepper.
• Pharmaceutical Research: Investigated as a lead compound or active ingredient in the development of novel topical analgesics, anesthetics, or anti-itch formulations due to its interaction with sensory neurons.
• Nutraceuticals & Functional Foods: Incorporated into dietary supplements or functional food products targeting oral health, digestive stimulation, or unique sensory experiences.
• Cosmetic & Personal Care: Potential use in formulations such as lip plumpers, sensitive skin creams, or oral care products (toothpaste, mouthwash) where a mild, transient numbing sensation is desired.
• Agrochemical Research: Studied for its potential as a natural insecticide or pest deterrent based on its bioactivity against certain insect nervous systems.
• Neuroscience & Physiology Studies: Serves as a valuable chemical tool for probing the mechanisms of somatosensation, specifically the activation of TRPV1 and KCNK channels.

Basic Information

Product Name	γ-Sanshool
CAS No.	78886-65-4
Molecular Formula	C₁₆H₂₅NO
Molecular Weight	247.38 g/mol
Synonyms	γ-Sanshool; (2E,6E,8E,10E)-N-(2-Hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide; Hydroxy-α-sanshool; Sanshool; Szechuan pepper extract; Zanthoxylum alkylamide; Fagaramide
EINECS	Contact for details

Quality Control

Our γ-Sanshool is produced and tested under strict quality management protocols. Each batch undergoes comprehensive analysis to ensure identity, purity, and consistency. We provide full traceability and support compliance with relevant standards for research and development purposes. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated place away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Solubility	Soluble in ethanol, DMSO, and most organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.