Description

Angiotensin I, Sar(1)- CAS NO 78809-83-3 is a synthetic peptide analog of the endogenous decapeptide Angiotensin I, specifically modified with sarcosine (Sar) at position 1. This structural modification is critical for enhancing its stability against enzymatic degradation, making it a valuable tool for biochemical and pharmacological research. It is primarily utilized by researchers and manufacturers in the pharmaceutical and life sciences industries for studying the renin-angiotensin system, developing enzyme inhibitors, and as a reference standard in analytical method development.

Application

• Biochemical Research: Used as a stable substrate or inhibitor in studies of the renin-angiotensin-aldosterone system (RAAS) and related enzymatic pathways.
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the research and development of cardiovascular drugs, including ACE inhibitors and angiotensin receptor blockers.
• Analytical Standard: Employed as a high-purity calibration standard in chromatographic (HPLC, LC-MS) and spectroscopic analyses for method validation and quality control.
• Enzyme Kinetics: Acts as a specific substrate for angiotensin-converting enzyme (ACE) to study enzyme activity, inhibition constants, and mechanism of action.
• Peptide Chemistry Studies: Utilized in structural-activity relationship (SAR) studies to understand the impact of N-terminal modifications on peptide stability and biological activity.

Basic Information

Item	Detail
Product Name	Angiotensin I, Sar(1)- CAS NO 78809-83-3
CAS No.	78809-83-3
Molecular Formula	C₄₉H₇₁N₁₃O₁₂
Molecular Weight	1034.2 g/mol
Synonyms	Sar¹-Angiotensin I; [Sar¹]-Angiotensin I; 1-Sarcosine-angiotensin I; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu (1-Sar); Angiotensin I (1-10), 1-sar-; N-Acetyl-Sar-Angiotensin I fragment 1-10; DRVYIHPFHL (1-Sar); Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
EINECS	Contact for details

Quality Control

Our Angiotensin I, Sar(1)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production standards. Specifications can meet the requirements for use as a reference material.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO), acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.