Description

Guanosine 5'-(Trihydrogen Diphosphate), 3'-o-Methyl- (9Ci) is a chemically modified nucleotide analog, specifically a methylated derivative of guanosine diphosphate. This compound is a critical building block and research tool in the fields of biochemistry and molecular biology, enabling the study of RNA structure, function, and enzymatic processes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in nucleotide synthesis, enzymology, and the development of novel therapeutic agents.

Application

• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly for RNA polymerases, GTPases, and other nucleotide-binding proteins.
• Nucleotide Analog Synthesis: Acts as a key intermediate in the chemical synthesis of modified nucleosides and nucleotides for structure-activity relationship (SAR) studies.
• RNA Metabolism Studies: Used to investigate RNA capping, splicing, and other post-transcriptional modification pathways where methylated guanosine derivatives play a role.
• Pharmaceutical Development: Employed in the research and development of antiviral or anticancer agents that target nucleotide metabolism.
• Diagnostic Reagent Formulation: Can be incorporated into enzymatic assay kits for the detection and quantification of specific biological activities.

Basic Information

Product Name	Guanosine 5'-(Trihydrogen Diphosphate), 3'-o-Methyl- (9Ci)
CAS No.	78771-34-3
Molecular Formula	C11H17N5O11P2
Molecular Weight	465.22 g/mol
Synonyms	3'-O-Methylguanosine 5'-diphosphate; 3'-O-Methyl-GDP; Guanosine, 5'-(trihydrogen diphosphate), 3'-O-methyl-; 3'-Methoxy-GDP; 9CI-Guanosine 5'-(trihydrogen diphosphate), 3'-O-methyl-; Methylated GDP analog; 3'-OMe-GDP
EINECS	Contact for details

Quality Control

Our production of high-purity biochemicals adheres to stringent quality protocols. Each batch of Guanosine 5'-(Trihydrogen Diphosphate), 3'-o-Methyl- (9Ci) is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV)
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.