Description

H-Val-Amc CAS NO 78682-66-3 is a high-purity, protected amino acid derivative widely utilized as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptide chains and other bioactive molecules, ensuring high coupling efficiency and minimal racemization. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutic peptides and proteomics research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of valine in automated peptide synthesizers.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: Serves as a versatile linker or spacer molecule for attaching fluorophores, tags, or other functional groups to peptides.
• Protease Substrate Development: Employed in the design and synthesis of specific substrates for enzyme activity assays and mechanistic studies.
• Combinatorial Chemistry Libraries: A valuable building block for creating diverse libraries of compounds for high-throughput screening in drug discovery.
• Academic and Industrial Research: Fundamental reagent for studying peptide structure, function, and metabolism in biochemical research.

Basic Information

Product Name	H-Val-Amc
CAS No.	78682-66-3
Molecular Formula	C₁₄H₁₈N₂O₃
Molecular Weight	262.31 g/mol
Synonyms	L-Valyl-7-amido-4-methylcoumarin; Val-AMC; Valine-AMC; N-(L-Valinyl)-7-amino-4-methylcoumarin; H-Val-7-amido-4-methylcoumarin; Valine AMC substrate; 7-(L-Valinamido)-4-methylcoumarin; N-Valyl-7-amino-4-methylcoumarin
EINECS	Contact for details

Quality Control

Our H-Val-Amc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.