Description

[[(2,5-Dioxopyrrolidin-1-Yl)Oxy]Carbonyl](4-Hydroxyphenyl)Acetic Acid is a high-purity, bifunctional chemical building block designed for advanced synthesis. This compound is critically important for its role as a versatile linker and activating agent in the development of pharmaceuticals and bioconjugates. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotech, and diagnostic sectors for creating targeted drug delivery systems and novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of complex drug molecules, particularly for antibody-drug conjugates (ADCs) and targeted therapies.
• Bioconjugation Chemistry: Used to covalently link bioactive molecules (like drugs or dyes) to proteins, antibodies, or peptides, enabling targeted delivery and imaging.
• Peptide Synthesis: Serves as an activated ester for the efficient coupling of amino acids or peptide fragments in solid-phase and solution-phase synthesis.
• Polymer Functionalization: Employed to introduce reactive phenolic or activated ester groups into polymer backbones for creating smart biomaterials and drug-eluting coatings.
• Diagnostic Reagent Production: Utilized in the manufacture of contrast agents and labeled compounds for medical imaging and in vitro diagnostics.
• Cross-linking Agent: Facilitates the formation of stable bonds between biomolecules in biochemical assays and material science applications.

Basic Information

Item	Details
Product Name	[[(2,5-Dioxopyrrolidin-1-Yl)Oxy]Carbonyl](4-Hydroxyphenyl)Acetic Acid
CAS No.	78641-42-6
Molecular Formula	C13H11NO7
Molecular Weight	293.23 g/mol
Synonyms	4-Hydroxyphenylacetic Acid N-Hydroxysuccinimide Ester; HPAE NHS Ester; (4-Hydroxyphenyl)acetic Acid Succinimidyl Ester; N-Succinimidyl 4-Hydroxyphenylacetate; 4-Hydroxyphenylacetic Acid, N-Succinimidyl Ester; 4-HPA-NHS; 4-Hydroxyphenylacetyl NHS Ester; 4-Hydroxybenzeneacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester
EINECS	Contact for details

Quality Control

Our [[(2,5-Dioxopyrrolidin-1-Yl)Oxy]Carbonyl](4-Hydroxyphenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with exacting standards for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.