Description

11-Oxahomoaminopterin is a specialized chemical compound of significant interest in advanced pharmaceutical research and development. Its unique structural features make it a valuable intermediate for synthesizing novel therapeutic agents, particularly in the field of oncology and targeted drug discovery. This high-purity compound is essential for research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in cutting-edge medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel folate antagonist analogs and targeted chemotherapeutic agents.
• Biochemical Research: Used as a reference standard or active compound in enzymatic studies and mechanism-of-action research related to dihydrofolate reductase (DHFR) inhibition.
• Medicinal Chemistry: Serves as a core scaffold for the design and development of new chemical entities (NCEs) with potential anti-cancer, anti-inflammatory, or anti-infective properties.
• Preclinical Development: Employed in in vitro and in vivo studies to evaluate pharmacokinetics, efficacy, and toxicity profiles of new drug candidates.
• Academic Research: Utilized by universities and research institutes for fundamental studies in chemical biology and drug-target interactions.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects and client-specific API development.

Basic Information

Product Name	11-Oxahomoaminopterin
CAS No.	78520-72-6
Molecular Formula	C20H23N7O6
Molecular Weight	457.44 g/mol
Synonyms	11-Oxaaminopterin; 11-Oxa-homoaminopterin; 2-[[4-[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]amino]pentanedioic acid; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, 11-oxa analog; Aminopterin analog, 11-oxa-; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, 11-oxa-
EINECS	Contact for details

Quality Control

Every batch of 11-Oxahomoaminopterin is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development applications, with specifications tailored to meet the stringent requirements of pharmaceutical-grade intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.