Description

7,8-Methanodihydrocodeinone is a synthetic opioid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of potent analgesic agents and is pivotal in studies exploring new mechanisms of pain management. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of controlled pharmaceutical substances. The material is supplied with a focus on high purity and consistency to meet the stringent requirements of these applications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent opioid analgesics and antitussives.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new compounds with targeted pharmacological profiles.
• Reference Standard: Serves as an analytical standard in quality control laboratories for the identification and quantification of related substances.
• Controlled Substance Analog Synthesis: Employed in authorized research for the synthesis and study of compounds related to scheduled drugs.
• Biochemical Research: Used in vitro studies to investigate interactions with opioid receptors (e.g., μ, κ, δ).
• Process Development: Aids in the optimization of synthetic routes and scaling up production for target active pharmaceutical ingredients (APIs).

Basic Information

Product Name	7,8-Methanodihydrocodeinone
CAS No.	78518-10-2
Molecular Formula	C₁₉H₂₁NO₄
Molecular Weight	327.38 g/mol
Synonyms	7,8-Methanodihydrocodeinone; 7,8-Dihydro-7,8-methanocodeinone; 7,8-Methano-7,8-dihydrocodeinone; 7,8-Methanomorphinan-6-one derivative; 6-Oxo-7,8-methanodihydrocodeine; 7,8-Methanodihydrocodeine-6-one; 7,8-Methano-7,8-dihydrocodeine-6-one; 7,8-Methanomorphinan-6-one, 7,8-dihydro-
EINECS	Contact for details

Quality Control

Our 7,8-Methanodihydrocodeinone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the nature of the compound, appropriate safety and security measures for handling controlled substance precursors must be observed.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.