Description

H-Ala-Ala-Phe-βna CAS NO 78497-23-1 is a synthetic tripeptide derivative, specifically a protected peptide sequence containing a β-naphthylalanine (βna) residue. This compound is a crucial building block and research tool in advanced peptide chemistry and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications ranging from drug discovery to biochemical studies.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the solid-phase or solution-phase synthesis of more complex therapeutic peptides and peptidomimetics.
• Protease Substrate/Analogue: Used in biochemical research as a substrate or inhibitor analogue to study enzyme kinetics, specificity, and mechanism of action of proteolytic enzymes like chymotrypsin.
• Fluorescence Studies: The β-naphthylalanine moiety can act as an intrinsic fluorescent probe for studying peptide-protein interactions, folding, and localization.
• Structure-Activity Relationship (SAR) Research: Employed to investigate the impact of aromatic amino acid substitutions on the biological activity, stability, and receptor binding of peptide leads.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in peptide manufacturing and analytical laboratories.

Basic Information

Product Name	H-Ala-Ala-Phe-βna
CAS No.	78497-23-1
Molecular Formula	C26H29N3O5
Molecular Weight	463.53 g/mol
Synonyms	Ala-Ala-Phe-β-Naphthylamide; L-Alanyl-L-alanyl-L-phenylalanyl-β-naphthylamide; AAF-βNA; H-Ala-Ala-Phe-βNA; Tripeptide substrate AAF-βNA; N-(2-Naphthyl)-L-alanyl-L-alanyl-L-phenylalaninamide; Chymotrypsin substrate III; Naphthylamide AAF
EINECS	Contact for details

Quality Control

Our H-Ala-Ala-Phe-βna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure enantiomeric purity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. Due to its hygroscopic nature, the product should be handled in a dry environment and containers must be kept tightly sealed after use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.