Description

1,2-Dimyristoyl-D54-3-Sn-Glycerophosphatidylcholine is a deuterium-labeled phospholipid, specifically a perdeuterated dimyristoylphosphatidylcholine (DMPC-d54). This compound is a critical tool in advanced biophysical research, offering unique spectroscopic properties for non-perturbative studies of membrane structure and dynamics. It is essential for scientists in pharmaceutical R&D, structural biology, and advanced material science who require precise isotopic labeling for techniques like NMR spectroscopy, neutron scattering, and mass spectrometry.

Application

• Biophysical Research: As a key component in creating model lipid bilayers and vesicles for studying membrane fluidity, phase transitions, and protein-lipid interactions using techniques such as Solid-State NMR and Neutron Scattering.
• Structural Biology: Used in the preparation of deuterated liposomes and bicelles to facilitate the structural elucidation of membrane proteins and peptides via solution and solid-state NMR.
• Drug Delivery System Development: Incorporated into the formulation of liposomal carriers to trace and study the stability, biodistribution, and release mechanisms of encapsulated active pharmaceutical ingredients (APIs).
• Metabolic Tracing & Proteomics: Serves as a stable isotope-labeled internal standard in mass spectrometry-based lipidomics and metabolic flux analysis for accurate quantification.
• Membrane Protein Crystallization: Employed to create a deuterated lipid environment that can improve the stability and crystallization success of challenging membrane protein targets.
• Advanced Material Science: Used in the development and characterization of bio-inspired materials, sensors, and supported lipid bilayers (SLBs) where isotopic contrast is required.

Basic Information

Product Name	1,2-Dimyristoyl-D54-3-Sn-Glycerophosphatidylcholine
CAS No.	78415-49-3
Molecular Formula	C36D54H14NO8P
Molecular Weight	~678.8 g/mol (for unlabeled form C36H72NO8P; exact mass for deuterated form varies)
Synonyms	DMPC-d54; 1,2-Ditetradecanoyl-D54-sn-glycero-3-phosphocholine; Deuterated DMPC; Perdeuterated Dimyristoylphosphatidylcholine; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d54; DMPC (dimyristoylphosphatidylcholine)-d54; 1,2-Dimyristoylphosphatidylcholine-d54; PC(14:0/14:0)-d54
EINECS	Contact for details

Quality Control

Our deuterated phospholipids are produced and handled under strict quality protocols to ensure high isotopic purity and chemical integrity. Each batch is characterized using a combination of analytical techniques including NMR spectroscopy, mass spectrometry (MS), and thin-layer chromatography (TLC) to confirm identity, isotopic enrichment (typically >98 atom % D), and chemical purity. Certificates of Analysis (COA) detailing lot-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Isotopic Purity (Atom % D)	>98% (by MS or NMR)
Chemical Purity (TLC/HPLC)	>95%
Solubility	Soluble in chloroform, methanol, ethanol; forms vesicles in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.