Description

Nepafenac CAS NO 78281-72-8 is a potent nonsteroidal anti-inflammatory drug (NSAID) prodrug specifically designed for ophthalmic use. Its primary value lies in its targeted action, where it is rapidly converted to amfenac in ocular tissues, providing effective relief from pain and inflammation following cataract surgery. This compound is essential for pharmaceutical manufacturers and research institutions developing advanced ophthalmic formulations. Its selective mechanism offers a favorable safety profile for sensitive ocular applications.

Application

• Primary Active Pharmaceutical Ingredient (API) in ophthalmic anti-inflammatory solutions and suspensions.
• Formulation Component for post-operative eye drops following cataract extraction and other ocular surgeries.
• Key Intermediate in the synthesis of related amfenac-based pharmaceutical compounds.
• Research Chemical for pharmacological studies targeting cyclooxygenase (COX) enzymes in ocular models.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Development Material for novel drug delivery systems, such as ocular inserts or sustained-release formulations.

Basic Information

Product Name	Nepafenac
CAS No.	78281-72-8
Molecular Formula	C15H14N2O2
Molecular Weight	254.28 g/mol
Synonyms	2-Amino-3-benzoylbenzeneacetamide; Nepafenacum; AHR-9434; AL-6515; Nevanac (Brand Name); (+)-2-Amino-3-benzoylbenzenecetamide; (2-Amino-3-benzoylphenyl)acetamide
EINECS	Contact for details

Quality Control

Our Nepafenac is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC and related substances tests. A Certificate of Analysis (COA) is provided with every shipment, detailing compliance with in-house specifications. We support development and regulatory needs with materials suitable for use as a Pharmaceutical Reference Standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.