Description

(+)-Tetrahydrozoline CAS NO 78213-24-8 is a high-purity, enantiomerically pure form of the imidazoline derivative, tetrahydrozoline. This compound is valued for its specific pharmacological activity as a selective α-adrenergic receptor agonist. It is an essential active pharmaceutical ingredient (API) and key intermediate for manufacturers in the pharmaceutical and advanced fine chemical sectors, particularly for ophthalmic and nasal decongestant formulations.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of prescription and over-the-counter (OTC) ophthalmic solutions (eye drops) for redness relief.
• Nasal Decongestant Formulations: Used as a vasoconstrictor in nasal sprays to relieve congestion.
• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of more complex adrenergic agents.
• Research & Development: A reference standard and tool compound for pharmacological studies targeting α-adrenergic receptors.
• Veterinary Pharmaceuticals: Employed in certain ophthalmic preparations for animal use.
• Controlled-Release Drug Delivery Systems: Investigational component in advanced drug delivery platforms.

Basic Information

Product Name	(+)-Tetrahydrozoline
CAS No.	78213-24-8
Molecular Formula	C13H16N2
Molecular Weight	200.28 g/mol
Synonyms	(+)-Tetrahydrozoline; (R)-Tetrahydrozoline; (4R)-4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole; d-Tetrahydrozoline; Tetrahydrozoline (R)-enantiomer; Tetrahydrozoline, (+)-; Tetrahydrozoline, (R)-; Visine (principal component)
EINECS	Contact for details

Quality Control

Our (+)-Tetrahydrozoline is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with typical purity levels exceeding 98.5% (by HPLC). Comprehensive testing includes chiral purity, identification, assay, and control of specified impurities. A Certificate of Analysis (COA) documenting compliance with agreed specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (R)-enantiomer
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.