Description

5-(Carboxymethylaminomethyl)-2-Thiouridine is a modified nucleoside derivative, a key building block in advanced biochemical research and synthesis. Its primary value lies in its role as a precursor for the synthesis of specialized oligonucleotides and tRNA analogs, enabling studies in molecular biology and nucleic acid chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on developing novel therapeutics, diagnostic tools, and exploring RNA structure and function.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a building block for incorporating thio-modifications into oligonucleotides to study RNA structure, stability, and function.
• tRNA Analogue Synthesis: Key component in the preparation of modified transfer RNA molecules for probing protein biosynthesis mechanisms.
• Probe and Diagnostic Development: Serves as a starting material for creating labeled nucleosides used in diagnostic assays and molecular probes.
• Antisense Technology: Utilized in the development of antisense oligonucleotides with enhanced nuclease resistance and binding affinity.
• Academic & Industrial R&D: Fundamental reagent for exploratory chemistry in universities and corporate R&D laboratories focusing on nucleic acid chemistry.

Basic Information

Product Name	5-(Carboxymethylaminomethyl)-2-Thiouridine
CAS No.	78173-95-2
Molecular Formula	C13H19N3O8S
Molecular Weight	377.37 g/mol
Synonyms	5-Carboxymethylaminomethyl-2-thiouridine; 2-Thio-5-carboxymethylaminomethyluridine; 5-[(Carboxymethyl)amino]methyl-2-thiouridine; CMAM2S2U; 2-Thiouridine, 5-[(carboxymethyl)amino]methyl]-; 5-(N-Carboxymethylaminomethyl)-2-thiouridine; s2cmnm5U (common tRNA modification context)
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our high-purity biochemical intermediates. Every batch of 5-(Carboxymethylaminomethyl)-2-Thiouridine is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality system supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.