Description

13-Cis Retinoyl B-D-Glucuronide is a specific, conjugated metabolite of 13-cis-retinoic acid (isotretinoin), formed via glucuronidation. This compound is of significant interest in pharmaceutical and dermatological research due to its role in retinoid metabolism and potential implications for drug efficacy and safety profiling. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories focused on metabolic studies, pharmacokinetics, and the development of novel retinoid-based therapies.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of isotretinoin metabolites in biological matrices.
• Metabolic Pathway Research: Used in in vitro and in vivo studies to elucidate the metabolic fate, bioavailability, and clearance mechanisms of 13-cis-retinoic acid.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-UV methods for therapeutic drug monitoring (TDM) and pharmacokinetic studies.
• Dermatology Research: Investigated for its biological activity and role in the mechanism of action of retinoid treatments for severe acne and other skin disorders.
• Toxicology & Safety Assessment: Employed in studies assessing the metabolic profile and potential long-term effects of retinoid therapies.

Basic Information

Product Name	13-Cis Retinoyl B-D-Glucuronide
CAS No.	78147-42-9
Molecular Formula	C26H36O8
Molecular Weight	476.56 g/mol
Synonyms	13-cis-Retinoyl β-D-glucuronide; Isotretinoin Glucuronide; 13-cis-Retinoic Acid Glucuronide; (2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid β-D-Glucopyranosiduronic Acid; 13-cis-Retinoyl-β-D-glucuronide; β-D-Glucopyranosiduronic acid, (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
EINECS	Contact for details

Quality Control

Our high-purity 13-Cis Retinoyl B-D-Glucuronide is manufactured under controlled conditions to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS). A comprehensive Certificate of Analysis (COA) detailing purity, chromatographic data, and storage recommendations is provided with every shipment to support your quality and compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. For long-term storage, desiccate at -80°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, methanol; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.