Description

5-Fluorouracil Tromethamine is a tromethamine salt derivative of the widely used antimetabolite and antineoplastic agent, 5-fluorouracil. This formulation is designed to enhance solubility and stability, making it a critical intermediate and active ingredient in advanced pharmaceutical research and development. It is essential for manufacturers and research institutions focused on oncology therapeutics, diagnostic agents, and innovative drug delivery systems requiring a more soluble form of this potent compound.

Application

• Oncological Pharmaceutical Development: Serves as a key active pharmaceutical ingredient (API) and intermediate in the synthesis of chemotherapeutic formulations.
• Research and Development: Used in biochemical and pharmacological studies to investigate mechanisms of action, efficacy, and new combination therapies for various cancers.
• Diagnostic Agent Synthesis: Acts as a precursor in the development of radiolabeled compounds for diagnostic imaging and research.
• Drug Delivery System Optimization: Employed in the development of novel delivery platforms, such as liposomal or nanoparticle-based systems, to improve therapeutic index and reduce side effects.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	5-Fluorouracil Tromethamine
CAS No.	78144-69-1
Molecular Formula	C9H15FN2O6
Molecular Weight	266.23 g/mol
Synonyms	5-FU Tromethamine Salt; 5-Fluorouracil Tromethamine Salt; 2,4-Dioxo-5-fluoropyrimidine Tromethamine Salt; 5-Fluoro-2,4(1H,3H)-pyrimidinedione Tromethamine; FT; FT-Salt; 5-Fluorouracil TRIS Salt; 5-FU TRIS Salt
EINECS	Contact for details

Quality Control

Our 5-Fluorouracil Tromethamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) detailing HPLC purity, residual solvents, and related substances are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.