Description

β-Phenyl-1,N2-Ethenoguanosine-3',5'-Cyclic Monophosphate Sodium Salt is a chemically modified, cell-permeable analog of cyclic GMP (cGMP) designed for advanced biochemical research. This compound matters as a potent and stable activator of cGMP-dependent protein kinases (PKG), enabling precise investigation of intracellular signaling pathways. It is primarily needed by researchers in pharmaceutical R&D, academic biochemistry, and molecular biology for studying cardiovascular function, neuronal signaling, and smooth muscle physiology.

Application

• Biochemical Research: As a potent and selective activator of protein kinase G (PKG) in cell-based assays and enzymatic studies.
• Cardiovascular Research: For investigating cGMP-mediated vasodilation, platelet aggregation inhibition, and cardiac contractility.
• Neuroscience Studies: Used to probe the role of cGMP signaling in synaptic plasticity, neurotransmitter release, and neuronal development.
• Smooth Muscle Physiology: Essential for research on relaxation mechanisms in vascular, bronchial, and gastrointestinal smooth muscle tissues.
• Drug Discovery & Screening: Serves as a critical reference standard and tool compound in high-throughput screening for novel PKG-targeted therapeutics.
• Signal Transduction Pathways: A key reagent for dissecting complex intracellular signaling cascades involving nitric oxide (NO) and natriuretic peptides.

Basic Information

Product Name	β-Phenyl-1,N2-Ethenoguanosine-3',5'-Cyclic Monophosphate Sodium Salt
CAS No.	78080-27-0
Molecular Formula	C₁₈H₁₅N₅O₇P • xNa
Molecular Weight	Contact for details
Synonyms	8-(4-Chlorophenylthio)-cGMP sodium salt; 8-pCPT-cGMP sodium salt; β-Phenyl-1,N2-etheno-cGMP sodium salt; cGMP analog, PKG activator; B-Phe-1,N2-ethenoguanosine cyclic 3',5'-(hydrogen phosphate) sodium salt; 8-(4-Chlorophenylthio)guanosine-3',5'-cyclic monophosphate sodium salt; Cell-permeable cGMP analog
EINECS	Contact for details

Quality Control

Our β-Phenyl-1,N2-Ethenoguanosine-3',5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management systems to ensure batch-to-batch consistency for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee material integrity and support your research compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term stability, store under inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.