Description

Tm-Dota (CAS NO 78063-83-9) is a highly specialized lanthanide chelate complex, valued for its exceptional stability and paramagnetic properties. This compound is critical for applications requiring precise molecular imaging and targeted diagnostics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors.

Application

• Magnetic Resonance Imaging (MRI) Contrast Agents: Serves as a key precursor or active component in the development of high-relaxivity, targeted contrast media.
• Radiopharmaceuticals & Nuclear Medicine: Used as a bifunctional chelator for labeling therapeutic and diagnostic radioisotopes (e.g., Lutetium-177, Yttrium-90) for targeted alpha/beta therapy (TAT/TRT) and PET/SPECT imaging.
• Bioconjugation & Probe Development: Acts as a stable linker for attaching imaging or therapeutic payloads to antibodies, peptides, and other targeting molecules.
• In Vitro Diagnostics (IVD): Employed in the formulation of sensitive assay reagents for fluorescence and luminescence-based detection systems.
• Catalysis Research: Functions as a Lewis acid catalyst or catalyst component in specialized organic synthesis and polymerization reactions.
• Material Science: Incorporated into advanced luminescent materials, dopants for optical fibers, and components in quantum information science research.

Basic Information

Product Name	Tm-Dota
CAS No.	78063-83-9
Molecular Formula	C16H24N4O8Tm
Molecular Weight	586.33 g/mol (approx.)
Synonyms	Thulium(III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate; Thulium-DOTA; Tm-DOTA; Tm(III)-DOTA complex; 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetatothulium; DOTATm; Thulium-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid complex
EINECS	Contact for details

Quality Control

Every batch of Tm-Dota is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity requirements for pharmaceutical and research applications. A detailed Certificate of Analysis (COA), including purity assay, identity confirmation, and impurity profiles, is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Thulium (Tm) Content	28.5 - 30.5 %
Free DOTA	≤ 2.0%
Water Content (KF)	≤ 5.0%
Heavy Metals (as Pb)	≤ 20 ppm
pH (1% Solution)	5.0 - 7.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.