Description

1-(Decanoylthio)-2-Decanoyl-3-Phosphatidylcholine is a synthetic, chemically defined phospholipid derivative, specifically a thioester analog of phosphatidylcholine. This compound is valued for its role as a key intermediate and functional building block in advanced lipid research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the liposome formulation, drug delivery system design, and membrane biochemistry sectors, where precise lipid structures are critical for functionality.

Application

• Liposome and Nanoparticle Formulation: As a functionalized phospholipid for constructing stable, targeted drug delivery vesicles.
• Biomimetic Membrane Research: For studying membrane dynamics, protein-lipid interactions, and signal transduction in model systems.
• Pharmaceutical Intermediates: Serves as a critical synthetic precursor for novel phospholipid-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Probe Development: The reactive thioester group enables site-specific labeling and conjugation with biomolecules for diagnostic applications.
• Excipient Development: Exploration of its use as a novel solubilizing or stabilizing agent in complex formulations.

Basic Information

Product Name	1-(Decanoylthio)-2-Decanoyl-3-Phosphatidylcholine
CAS No.	77912-87-9
Molecular Formula	C38H74NO8PS
Molecular Weight	735.99 g/mol
Synonyms	1-Decanoylthio-2-decanoyl-sn-glycero-3-phosphocholine; Decanoylthio Phosphatidylcholine; 1-Thiodecanoyl-2-decanoylphosphatidylcholine; S-Decanoyl Phosphatidylcholine Thioester; PC(10:0/10:0) Thioester Analog; 1,2-Didecanoyl-sn-glycero-3-phosphothiocholine (related); Synthetic Thiolipid; Phospholipid Thioester
EINECS	Contact for details

Quality Control

Our 1-(Decanoylthio)-2-Decanoyl-3-Phosphatidylcholine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.