Description

H-Val-Pna Hcl is a protected amino acid derivative, specifically the hydrochloride salt of N-(p-Nitroanilino)valine. This compound serves as a critical building block in the synthesis of complex peptides and other bioactive molecules, offering precise control over molecular structure. It is primarily utilized by pharmaceutical research organizations and fine chemical manufacturers engaged in advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected valine derivative to introduce specific amino acid sequences.
• Bioconjugation: Employed in the development of peptide-protein conjugates and other bioconjugates for therapeutic and diagnostic applications.
• Chemical Biology Research: Serves as a tool compound for studying enzyme-substrate interactions and designing enzyme inhibitors.
• Fine Chemical Production: Acts as a specialized intermediate in the multi-step synthesis of complex organic molecules for high-value markets.

Basic Information

Product Name	H-Val-Pna Hcl
CAS No.	77835-49-5
Molecular Formula	C₁₁H₁₅N₃O₃·HCl
Molecular Weight	273.72 g/mol
Synonyms	L-Valine, N-(4-nitrophenyl)-, hydrochloride; N-(4-Nitrophenyl)-L-valine hydrochloride; N4-(p-Nitroanilino)-L-valine hydrochloride; Val-PNA HCl; H-Val-pNA·HCl; (S)-2-Amino-3-methyl-N-(4-nitrophenyl)butanamide hydrochloride; p-Nitroanilide of Valine hydrochloride
EINECS	Contact for details

Quality Control

Our H-Val-Pna Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the stringent requirements for research and synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.