Description

3-[3-(2-Iodoacetamido)Propylcarbamoyl]-Proxyl is a stable nitroxide radical spin label, widely recognized for its utility in probing biomolecular structure and dynamics. Its core value lies in its ability to covalently attach to cysteine residues via its iodoacetamide functional group, enabling site-directed spin labeling for advanced Electron Paramagnetic Resonance (EPR) spectroscopy studies. This compound is essential for researchers and developers in structural biology, biophysics, and pharmaceutical sciences who require precise tools for investigating protein conformation, folding, and interactions.

Application

• Site-Directed Spin Labeling (SDSL) for EPR spectroscopy studies of proteins and nucleic acids.
• Probing protein dynamics, folding pathways, and conformational changes in solution.
• Investigation of membrane protein structure and lipid-protein interactions.
• Use as a molecular probe in biophysical research to measure distances and mobility.
• Development of diagnostic assays and biosensors based on EPR detection.
• Fundamental research in free radical chemistry and nitroxide applications.

Basic Information

Product Name	3-[3-(2-Iodoacetamido)Propylcarbamoyl]-Proxyl
CAS No.	77695-02-4
Molecular Formula	C₁₄H₂₃IN₄O₃
Molecular Weight	422.16 g/mol
Synonyms	3-(3-(2-Iodoacetamido)propylcarbamoyl)-PROXYL; Iodoacetamide-Proxyl; 3-Carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxy, 3-[(3-((iodoacetyl)amino)propyl)carbamoyl]-; PROXYL Iodoacetamide; 3-(3-(2-Iodoacetamido)propylcarbamoyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; 3-Maleimido-PROXYL Iodoacetamide derivative; Spin label iodoacetamide
EINECS	Contact for details

Quality Control

Our 3-[3-(2-Iodoacetamido)Propylcarbamoyl]-Proxyl is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.