Description

1-[(2'-Hydroxyethoxy)-Methyl]-5-Fluorouracil is a chemically modified derivative of the established antimetabolite 5-fluorouracil (5-FU), designed to enhance its therapeutic profile. This compound is significant for its potential to improve drug delivery, solubility, and targeted action in pharmaceutical research and development. It is primarily needed by pharmaceutical manufacturers and research institutions engaged in the development of novel oncology therapeutics and prodrug systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced anticancer prodrugs and novel chemotherapeutic agents.
• Oncology Research: Used in preclinical and clinical research to study modified fluoropyrimidines with potentially improved efficacy and reduced side-effect profiles.
• Prodrug Development: Exploited in the design of prodrugs aimed at enhancing tumor selectivity and the bioavailability of 5-fluorouracil.
• Bioconjugation Studies: Acts as a modified nucleoside analog for conjugation with antibodies, polymers, or other targeting moieties in targeted cancer therapy research.
• Chemical Biology Tool: Utilized as a probe to investigate cellular uptake mechanisms and the metabolism of fluorouracil analogs.

Basic Information

Product Name	1-[(2'-Hydroxyethoxy)-Methyl]-5-Fluorouracil
CAS No.	77474-50-1
Molecular Formula	C8H11FN2O4
Molecular Weight	218.18 g/mol
Synonyms	5-Fluoro-1-[(2-hydroxyethoxy)methyl]uracil; 1-(2-Hydroxyethoxymethyl)-5-fluorouracil; 5-FU HEM; HEM-5-FU; 1-[(2-Hydroxyethoxy)methyl]-5-fluorouracil; 5-Fluorouracil, 1-[(2-hydroxyethoxy)methyl]-; N1-(2-Hydroxyethoxymethyl)-5-fluorouracil
EINECS	Contact for details

Quality Control

Our 1-[(2'-Hydroxyethoxy)-Methyl]-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.