Description

1-[(2'-Acetoxyethoxy)Methyl]-5-Fluorouracil CAS NO 77474-49-8 is a chemically modified derivative of the established antimetabolite 5-fluorouracil (5-FU), designed to enhance its therapeutic profile. This compound matters for its potential to improve drug delivery, targeting, and bioavailability in pharmaceutical applications, offering a pathway to more effective and selective treatments. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel oncology therapeutics and prodrug systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced prodrugs and targeted chemotherapeutic agents.
• Oncology Research: Used in preclinical and clinical research to study improved formulations and delivery mechanisms for 5-FU-based cancer therapies.
• Prodrug Development: Exploited for creating compounds with enhanced tumor selectivity and reduced systemic toxicity compared to the parent drug.
• Chemical Synthesis: Acts as a specialized reagent in organic and medicinal chemistry for introducing fluoropyrimidine motifs into complex molecules.
• Drug Delivery Systems: Incorporated into polymer-drug conjugates or liposomal formulations to control release kinetics and improve pharmacokinetics.

Basic Information

Product Name	1-[(2'-Acetoxyethoxy)Methyl]-5-Fluorouracil
CAS No.	77474-49-8
Molecular Formula	C10H11FN2O5
Molecular Weight	258.20 g/mol
Synonyms	5-FU O1-(2-Acetoxyethoxymethyl) Derivative; 1-[(2-Acetoxyethoxy)methyl]-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-Fluorouracil 1-(2-Acetoxyethoxymethyl) Derivative; 5-Fluorouracil O1-acetoxymethyl ether; 1-(Acetoxyethoxymethyl)-5-fluorouracil; N1-(2-Acetoxyethoxymethyl)-5-fluorouracil; AEM-FU; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-[(2'-Acetoxyethoxy)Methyl]-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider conditions under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.