Description

H-Hyp-Amc CAS NO 77471-43-3 is a specialized amino acid derivative, specifically a protected form of hydroxyproline, which serves as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity, structurally defined intermediates for complex molecule construction. It is primarily utilized by the pharmaceutical, biotechnology, and advanced materials sectors for applications in peptide synthesis, drug discovery, and the development of novel biomaterials.

Application

• Peptide Synthesis: As a key protected amino acid precursor for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for collagen-targeting therapies.
• Bioconjugation & Labeling: Used in the modification and functionalization of proteins, antibodies, and other biomolecules for diagnostic and therapeutic purposes.
• Biomaterials Research: Employed in the design and synthesis of novel hydrogels, scaffolds, and other materials for tissue engineering and regenerative medicine.
• Chemical Biology Probes: Acts as a component in the creation of specialized probes and inhibitors for studying enzyme function and biological pathways.
• Cosmeceutical Actives: Utilized in the development of high-end skincare ingredients that aim to support collagen structure and skin health.

Basic Information

Product Name	H-Hyp-Amc
CAS No.	77471-43-3
Molecular Formula	C11H12N2O4
Molecular Weight	236.22 g/mol
Synonyms	Fmoc-Hyp-OH; N-α-Fmoc-trans-4-hydroxy-L-proline; Fmoc-4-hydroxy-L-proline; (2S,4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxy-L-proline; Fmoc-L-hydroxyproline; Fmoc-trans-4-hydroxy-L-proline; Fmoc-Hyp
EINECS	Contact for details

Quality Control

Our H-Hyp-Amc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed in a desiccated environment to prevent moisture uptake, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-70.0° to -76.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.