Description

5-Hydroxy-6-Methoxyindole Glucuronide is a high-purity biochemical reference standard and metabolite of significant interest in advanced research and development. This compound serves as a critical analytical standard for the precise quantification and study of metabolic pathways, particularly those involving indole derivatives. It is primarily utilized by pharmaceutical R&D laboratories, clinical diagnostic developers, and academic institutions focused on metabolomics, biomarker discovery, and pharmacokinetic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration of analytical instruments in drug metabolism and pharmacokinetics (DMPK) studies.
• Biomarker Research: Serves as a key metabolite standard in the investigation and validation of potential biomarkers for diagnostic assays.
• Clinical Diagnostics: Employed in the development and quality control of high-sensitivity diagnostic tests, such as LC-MS/MS assays, for accurate patient sample analysis.
• Metabolomics & Systems Biology: A vital component in metabolic pathway mapping and profiling studies to understand biological systems and disease states.
• Enzymology Studies: Used as a substrate or product in studies involving glucuronidation enzymes like UDP-glucuronosyltransferases (UGTs).
• Toxicology & Safety Assessment: Applied in research to understand the detoxification and excretion pathways of xenobiotics and pharmaceuticals.

Basic Information

Product Name	5-Hydroxy-6-Methoxyindole Glucuronide
CAS No.	77463-71-9
Molecular Formula	C₁₆H₁₉NO₉
Molecular Weight	369.32 g/mol
Synonyms	5-Hydroxy-6-methoxy-1H-indol-3-yl β-D-glucopyranosiduronic acid; 6-Methoxy-5-hydroxyindole glucuronide; 5-Hydroxy-6-methoxyindoxyl glucuronide; Indole glucuronide derivative; 5-OH-6-MeO-indole glucuronide; HMIG; 3-(β-D-Glucopyranuronosyloxy)-5-hydroxy-6-methoxy-1H-indole
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxy-6-Methoxyindole Glucuronide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our quality protocols are designed to meet the stringent requirements of research and diagnostic applications. A detailed Certificate of Analysis (COA) providing batch-specific data for parameters including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis is supplied with each order.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.