Description

Flunisolide is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. This active pharmaceutical ingredient (API) is a critical component in the formulation of respiratory medications, primarily used to manage chronic inflammatory conditions. It is essential for pharmaceutical manufacturers developing nasal sprays and inhalers for the treatment of allergic and non-allergic rhinitis as well as asthma. Flunisolide CAS NO 77326-96-6 offers reliable efficacy in controlling upper airway inflammation.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription metered-dose inhalers (MDIs) for asthma maintenance therapy.
• Nasal Corticosteroid Sprays: Formulation into aqueous nasal sprays for the treatment of seasonal and perennial allergic rhinitis.
• Anti-inflammatory Preparations: Used in topical formulations for reducing inflammation in specific dermatological conditions, under medical supervision.
• Respiratory Drug Development: Serves as a reference standard and key intermediate in R&D for novel pulmonary delivery systems.
• Veterinary Pharmaceuticals: Potential application in anti-inflammatory treatments for companion animals.
• Clinical Research: Utilized as a biochemical tool in pharmacological studies of glucocorticoid receptor activity.

Basic Information

Product Name	Flunisolide
CAS No.	77326-96-6
Molecular Formula	C24H31FO6
Molecular Weight	434.50 g/mol
Synonyms	6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; 6α-Fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; RS-3999; 6α-Fluorotriamcinolone acetonide; Fluoxiprednisolone acetonide; Adenocort; Nasalide; Aerobid; Bronalide; Syntaris
EINECS	Contact for details

Quality Control

Our Flunisolide is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical use, with typical specifications aligning with pharmacopeial guidelines. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, assay, purity, and specified impurities. We support compliance with cGMP, ICH Q7, and relevant regulatory frameworks (FDA, EMA).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere packing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.