Description

N2-Ethylguanosine is a modified nucleoside analog of guanosine, where an ethyl group is substituted at the N2 position of the guanine base. This specific structural modification is of significant interest in biochemical and pharmaceutical research for studying nucleic acid interactions and developing novel therapeutic agents. It serves as a critical building block and reference standard for researchers in medicinal chemistry and molecular biology. The compound is primarily utilized in the synthesis of oligonucleotides and as a key intermediate in the development of antiviral and anticancer drug candidates.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel nucleoside-based antiviral and anticancer therapeutics.
• Biochemical Research: Used as a reference standard and probe in studies of RNA structure, function, and enzyme mechanisms (e.g., methyltransferases).
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite building block for introducing specific modifications into synthetic DNA or RNA strands.
• Diagnostic Development: Potential use in the development of diagnostic assays and sensors that rely on specific nucleic acid recognition.
• Academic & Institutional Research: Fundamental research tool in universities and institutes for investigating nucleoside chemistry and metabolism.
• Standards & Metrology: High-purity material for use as a certified reference standard in analytical laboratories.

Basic Information

Product Name	N2-Ethylguanosine
CAS No.	77312-39-1
Molecular Formula	C₁₂H₁₇N₅O₅
Molecular Weight	311.30 g/mol
Synonyms	2-Ethylaminoguanosine; N2-Ethylguanosine; Guanosine, N2-ethyl-; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(ethylamino)-1H-purin-6-one; 2-(Ethylamino)guanosine; N2-Et-Guo
EINECS	Contact for details

Quality Control

Our N2-Ethylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production standards. Specifications can be tailored to meet specific requirements for pharmaceutical development (GMP) or high-purity research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.