Description

Succinimidyl Propionate, n-, [Propionate-2,3-3H] CAS NO 77074-14-7 is a tritium-labeled active ester reagent used for the site-specific introduction of radioactive tags into biomolecules. This compound is critical for researchers requiring high-specific-activity tracers for sensitive detection and quantification in biological systems. It is primarily utilized in pharmaceutical R&D, biochemistry, and molecular biology for applications such as pharmacokinetic studies, receptor binding assays, and metabolic pathway analysis.

Application

• Radiolabeling of Biomolecules: Primary reagent for introducing tritium (3H) labels into proteins, peptides, and antibodies via amine-reactive succinimidyl ester chemistry.
• Pharmacokinetic and ADME Studies: Used to create radiolabeled drug candidates for tracking absorption, distribution, metabolism, and excretion in preclinical research.
• Receptor-Ligand Binding Assays: Enables the synthesis of high-specific-activity radioligands for studying receptor occupancy and binding affinity.
• Metabolic Pathway Tracing: Serves as a precursor for synthesizing tracers to elucidate biochemical pathways and metabolite identification.
• Diagnostic Probe Development: Facilitates the creation of radioactive probes for imaging and diagnostic applications.
• Quality Control in Radiopharmaceuticals: Used in the synthesis and quality testing of novel radiopharmaceutical compounds.

Basic Information

Product Name	Succinimidyl Propionate, n-, [Propionate-2,3-3H]
CAS No.	77074-14-7
Molecular Formula	C7H83HNO4 *
Molecular Weight	~174.15 g/mol (unlabeled) *
Synonyms	N-Hydroxysuccinimide Propionate-2,3-3H; NHS-Propionate-3H; [2,3-3H]Propionic Acid N-Hydroxysuccinimide Ester; Tritiated NHS-Propionate; 3H-SPA; N-Succinimidyl [2,3-3H]propionate; Propionic-2,3-3H Acid Succinimidyl Ester
EINECS	Contact for details

* Exact values depend on the specific activity and isotopic enrichment. Contact us for detailed specifications.

Quality Control

Every batch of our tritium-labeled reagents is produced and analyzed under strict quality systems to ensure radiochemical purity, specific activity, and chemical stability. Our quality control protocols are designed to meet the stringent requirements of research and development laboratories. Certificates of Analysis (COA) detailing specific activity, radiochemical purity (by HPLC), chemical purity, and solvent composition are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the vial sealed under an inert atmosphere and avoid repeated freeze-thaw cycles to maintain stability and specific activity.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (HPLC/MS)	Conforms
Specific Activity	10-100 Ci/mmol (Typical range)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 90%
Solvent	Toluene, Ethanol, or other anhydrous aprotic solvent
Concentration	1 mCi/mL (Typical)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.