Description

Cytidine 5'-Phosphoromorpholidate N,N'-Dicyclohexyl-4-Morpholinecarboximidamide is a specialized phosphoramidite reagent, a key building block in oligonucleotide synthesis. Its primary value lies in enabling the controlled, high-yield formation of internucleotide bonds, which is critical for producing research-grade and therapeutic nucleic acids. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical, biotechnology, and diagnostic sectors focused on antisense oligonucleotides, siRNA, and other advanced genetic medicines.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of DNA and RNA strands.
• Antisense Oligonucleotide (ASO) Production: Manufacturing of therapeutic oligonucleotides for targeting specific RNA sequences.
• Small Interfering RNA (siRNA) Synthesis: Critical for constructing siRNA duplexes used in gene silencing research and therapeutics.
• Diagnostic Probe Development: Synthesis of labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Research & Development: Synthesis of modified nucleosides and nucleotides for structure-activity relationship (SAR) studies.
• Scale-Up cGMP Manufacturing: Serves as a starting material for the production of active pharmaceutical ingredients (APIs) in oligonucleotide-based drugs under controlled conditions.

Basic Information

Product Name	Cytidine 5'-Phosphoromorpholidate N,N'-Dicyclohexyl-4-Morpholinecarboximidamide
CAS No.	76742-18-2
Molecular Formula	C24H40N5O7P
Molecular Weight	541.58 g/mol
Synonyms	Cytidine 5'-Monophosphomorpholidate; 5'-Cytidylic Acid Morpholidate; Cytidine 5'-Monophosphomorpholidate 4-Morpholine-N,N'-dicyclohexylcarboximidamide; Cytidine 5'-Phosphomorpholidate; CMP-Morpholidate; Cytidine 5'-Monophosphoromorpholidate; 5'-CMP Morpholidate; Cytidine 5'-Phosphoromorpholidate 4-Morpholine-N,N'-dicyclohexylcarboximidamide Salt
EINECS	Contact for details

Quality Control

Our Cytidine 5'-Phosphoromorpholidate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for sensitive oligonucleotide synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards required for research, diagnostic, and cGMP-grade pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) and in a moisture-controlled environment to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.