Description

4-Bromo-A23187 is a brominated derivative of the well-known calcium ionophore A23187, a critical tool compound in biochemical and pharmacological research. This modified version is valued for its enhanced stability and specific utility in studying intracellular calcium signaling pathways and ion transport mechanisms. It is primarily utilized by researchers and development scientists in the pharmaceutical, biotechnology, and life sciences sectors for advanced cell biology studies and assay development.

Application

• Biochemical Research: As a potent calcium ionophore for modulating intracellular calcium concentrations in experimental cell systems.
• Pharmacology Studies: Investigating calcium-dependent cellular processes, including signal transduction, enzyme activation, and neurotransmitter release.
• Cell Biology Assays: Used in fluorescence-based assays and flow cytometry to study calcium flux and homeostasis.
• Ion Channel Research: A tool for probing the function and regulation of calcium channels and transporters.
• Drug Discovery Screening: Employed in high-throughput screening platforms to identify novel modulators of calcium signaling pathways.
• Academic & Institutional Research: Fundamental research in universities and institutes focusing on cellular physiology and metal ion biology.

Basic Information

Product Name	4-Bromo-A23187
CAS No.	76455-48-6
Molecular Formula	C₂₉H₃₇BrN₂O₆
Molecular Weight	601.52 g/mol
Synonyms	4-Bromo-A23187; 4-Bromo Calcimycin; 4-Bromo Antibiotic A23187; Bromo A23187; 4-Br-A23187; 4-Bromo calcium ionophore A23187; 4-Bromo-5-(methylamino)-2-[[(2S,3R,5S,6R)-2,3,5,6-tetrahydro-6-hydroxy-2,5-dimethyl-3-(1-oxobutyl)-2H-pyran-4-yl]methyl]-4-benzoxazolecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Bromo-A23187 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.