Description

Phorbol 13-Decanoate is a specific, high-purity ester derivative of the phorbol diterpene core structure. This compound is of significant value as a precise biochemical tool and reference standard in life science research. It is primarily required by pharmaceutical R&D laboratories, academic institutions, and biotechnology companies engaged in signal transduction studies, particularly those investigating protein kinase C (PKC) activation pathways and related biological mechanisms.

Application

• Biochemical Research: Used as a potent and specific activator of Protein Kinase C (PKC) isoforms in cell-based and cell-free assays.
• Pharmacological Studies: Serves as a critical tool compound for studying PKC-mediated signal transduction, cellular proliferation, differentiation, and apoptosis.
• Reference Standard: Employed as a high-purity analytical standard for the identification and quantification of phorbol esters in various matrices.
• Tumor Promotion Research: Utilized in experimental models to study the mechanisms of tumor promotion and co-carcinogenesis.
• Drug Discovery: Acts as a key pharmacological probe in screening programs aimed at discovering novel PKC inhibitors or modulators.
• Toxicology & Safety Assessment: Applied in studies assessing the biological activity and potential risks of phorbol ester contaminants.

Basic Information

Product Name	Phorbol 13-Decanoate
CAS No.	76423-69-3
Molecular Formula	C30H44O8
Molecular Weight	532.67 g/mol
Synonyms	13-Decanoylphorbol; Phorbol 13-decanoate; 12-O-Tetradecanoylphorbol-13-decanoate (TPA analog); 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 13-decanoate; NSC 326223; 13-O-Decanoylphorbol; Phorbol-13-decanoic acid ester
EINECS	Contact for details

Quality Control

Our Phorbol 13-Decanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.