Description

O(6)-n-Butylguanine is a chemically modified nucleobase derivative, specifically an alkylated guanine analog. This compound is of significant value in biochemical and pharmaceutical research as a key intermediate and reference standard for studying DNA alkylation damage and repair mechanisms. It is primarily utilized by researchers and manufacturers in the fields of oncology research, molecular biology, and the development of chemotherapeutic agents and DNA repair enzyme inhibitors.

Application

• Biochemical Research: A critical reference standard and substrate for studying the activity of DNA repair enzymes, particularly O6-alkylguanine-DNA alkyltransferase (AGT).
• Oncology & Cancer Research: Used in the investigation of DNA damage response pathways and the development of strategies to overcome chemotherapy resistance.
• Pharmaceutical Intermediate: Serves as a key synthetic building block in the preparation of more complex nucleoside analogs and potential therapeutic agents.
• Molecular Probe Development: Employed in the design and synthesis of probes for labeling and tracking specific DNA repair proteins in cellular systems.
• Toxicology Studies: Used as a model compound to understand the biological consequences and mutagenic potential of specific DNA adducts.
• Academic Research: Fundamental tool in university and institutional labs for exploring nucleic acid chemistry and repair mechanisms.

Basic Information

Product Name	O(6)-n-Butylguanine
CAS No.	76412-62-9
Molecular Formula	C9H13N5O
Molecular Weight	207.23 g/mol
Synonyms	O6-n-Butylguanine; O6-Butylguanine; 2-Amino-6-(butyloxy)-9H-purine; 6-Butoxyguanine; Guanine, O6-butyl-; 9H-Purin-6-amine, 2-amino-6-butoxy-; O6-ButG
EINECS	Contact for details

Quality Control

Our O(6)-n-Butylguanine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.