Description

Disuccinimidyl Suberate is a homobifunctional, amine-reactive crosslinking agent featuring an 8-atom spacer arm. This compound is essential for creating stable covalent bonds between primary amines, enabling the conjugation of biomolecules such as proteins, peptides, and antibodies. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and proteomics, where precise and stable molecular linkages are required.

Application

• Bioconjugation and Protein Crosslinking: For linking proteins, peptides, or antibodies to other molecules, surfaces, or carriers.
• Antibody-Drug Conjugate (ADC) Synthesis: As a key linker molecule to attach cytotoxic payloads to monoclonal antibodies.
• Immunoassay Development: For preparing enzyme-antibody or hapten-carrier protein conjugates used in ELISA and other diagnostic assays.
• Immobilization Chemistry: For covalently attaching biomolecules to solid supports like beads, plates, or sensor chips.
• Proteomics and Structural Biology Research: To study protein-protein interactions and complex structures.
• Materials Science: For modifying surfaces and creating functionalized polymers with bioactive properties.

Basic Information

Product Name	Disuccinimidyl Suberate
CAS No.	76403-92-4
Molecular Formula	C20H28N2O8
Molecular Weight	424.45 g/mol
Synonyms	DSS; Suberic Acid Bis(N-hydroxysuccinimide Ester); Bis(N-succinimidyl) Suberate; N,N'-Disuccinimidyl Suberate; Suberic Acid Bis(2,5-dioxopyrrolidin-1-yl) Ester; 1,8-Bis(2,5-dioxo-1-pyrrolidinyl) Octanedioate; BS3 (a common abbreviation); Homobifunctional NHS Ester Crosslinker
EINECS	Contact for details

Quality Control

Our Disuccinimidyl Suberate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive life science applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material for research and GMP-grade applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.